ZNF613

Across TCGA patient cohorts, ZNF613 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF613-associated genes across cancer lineages are EGFR_pY1068, Chk2_pT68, and 4E-BP1. Each is linked with ZNF613 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF613-to-partner and partner-to-ZNF613 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZNF613-low versus ZNF613-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF613→partner) and Y-score (partner→ZNF613) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.284	-2.584	.003	.001	3	2
UCEC	Chk2_pT68 →	-0.175	-1.990	.014	.030	2	3
UCEC	4E-BP1 →	+0.240	+2.489	.020	.010	3	2
UCEC	14-3-3_beta →	-0.077	-2.432	.046	.018	3	1
UCEC	eEF2 →	+0.338	+3.169	.013	.018	3	1
UCEC	A-Raf_pS299 →	-0.100	-2.000	.028	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

EGFR_pY1068 by ZNF613 expression — UCEC

Explore this box plot interactively →