Across TCGA patient cohorts, ZNF611 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF611-associated genes across cancer lineages are JNK2, MEK1, and Notch1. Each is linked with ZNF611 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF611-to-partner and partner-to-ZNF611 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF611→partner) and Y-score (partner→ZNF611) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK2 →	+0.174	+1.643	.004	.003	3	2
UCEC	MEK1 →	+0.427	+2.169	<.001	<.001	3	2
UCEC	Notch1 →	+0.131	+1.643	.002	.003	3	2
UCEC	Shc_pY317 →	-0.142	-2.321	.002	.005	3	2
UCEC	XBP1 →	-0.106	-1.893	.015	.014	3	2
UCEC	Caspase-7-cleavedD198 →	+0.450	+1.584	.014	.032	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

Exploration

ZNF611 survival (RNA) · tumor vs normal (RNA) · all ZNF611 data types