ZNF610

Across TCGA patient cohorts, ZNF610 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF610-associated genes across cancer lineages are MEK1, PCNA, and ASNS. Each is linked with ZNF610 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF610-to-partner and partner-to-ZNF610 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ZNF610-low versus ZNF610-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF610→partner) and Y-score (partner→ZNF610) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.487	+2.736	<.001	<.001	3	2
UCEC	PCNA →	+0.184	+2.999	.020	.035	3	2
COAD	ASNS →	+0.755	+2.815	<.001	.036	3	2
UCEC	EGFR_pY1068 →	-0.185	-2.000	.044	.030	3	1
UCEC	eIF4G →	+0.224	+1.874	.049	.049	3	1
UCEC	INPP4B →	-0.272	-3.584	.022	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

MEK1 by ZNF610 expression — UCEC

Explore this box plot interactively →