ZNF609

Across TCGA patient cohorts, ZNF609 mutation is significantly associated with the RNA expression of many other genes, with 5,984 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF609-associated genes across cancer lineages are KCTD9, TIFA, and CCL5. Each is linked with ZNF609 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF609-to-partner and partner-to-ZNF609 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, KCTD9 grouped by ZNF609-low versus ZNF609-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF609→partner) and Y-score (partner→ZNF609) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	KCTD9 →	+0.612	+1.836	<.001	<.001	3	4
UCEC	TIFA →	+0.321	+1.373	.004	.001	3	4
UCEC	CCL5 →	+1.155	+1.847	<.001	<.001	3	3
SKCM	CCL4 →	+0.987	+1.906	.002	.001	3	3
COAD	CCL3 →	+1.016	+2.820	.001	.001	3	3
SKCM	CLEC7A →	+0.648	+2.604	.004	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,984 associations by consensus.

KCTD9 by ZNF609 expression — UCEC

Explore this box plot interactively →