ZNF609

Across TCGA patient cohorts, ZNF609 mutation is significantly associated with the total protein of many other genes, with 48 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF609-associated genes across cancer lineages are Caspase-7-cleavedD198, c-Met_pY1235, and ATM. Each is linked with ZNF609 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF609-to-partner and partner-to-ZNF609 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by ZNF609-low versus ZNF609-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF609→partner) and Y-score (partner→ZNF609) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	Caspase-7-cleavedD198 →	+1.389	+3.467	<.001	.002	3	4
SKCM	c-Met_pY1235 →	+0.114	+3.584	<.001	.002	3	3
UCEC	ATM →	-0.380	-1.447	.002	.002	3	3
COAD	eEF2 →	+0.362	+3.169	.006	.018	3	2
UCEC	MEK1 →	+0.487	+2.280	<.001	<.001	3	2
COAD	PCNA →	+0.267	+2.330	.017	.020	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 48 associations by consensus.

Caspase-7-cleavedD198 by ZNF609 expression — COAD

Explore this box plot interactively →