ZNF609

Across TCGA cell cohorts, ZNF609 mutation is significantly associated with the RNA expression of many other genes, with 303 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF609-associated genes across cancer lineages are SFT2D3, OTOP1, and SNTG2. Each is linked with ZNF609 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF609-to-partner and partner-to-ZNF609 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SFT2D3 grouped by ZNF609-low versus ZNF609-high in PANCREAS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF609→partner) and Y-score (partner→ZNF609) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	SFT2D3 →	+1.366	+4.237	<.001	.006	3	2
CNS	OTOP1 →	+0.150	+2.730	.005	.008	3	2
CNS	SNTG2 →	+0.678	+3.500	<.001	.008	3	2
BREAST	C1orf141 →	+0.030	+4.196	<.001	.006	3	2
LUNG_NSCLC_LUAD	OR1G1 →	+0.028	+3.604	<.001	.004	3	2
LARGE_INTESTINE	SULT1C3 →	+0.414	+2.577	.002	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 303 associations by consensus.

SFT2D3 by ZNF609 expression — PANCREAS

Explore this box plot interactively →