ZNF606

Across TCGA patient cohorts, ZNF606 mutation is significantly associated with the total protein of many other genes, with 30 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF606-associated genes across cancer lineages are p62 Lck ligand, eIF4E, and MEK1. Each is linked with ZNF606 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF606-to-partner and partner-to-ZNF606 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ZNF606-low versus ZNF606-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF606→partner) and Y-score (partner→ZNF606) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.270	+1.687	.006	.013	3	3
UCEC	eIF4E →	+0.189	+3.920	.003	<.001	3	2
UCEC	MEK1 →	+0.407	+2.662	<.001	<.001	3	2
UCEC	PCNA →	+0.273	+2.536	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.352	-2.000	<.001	.002	3	2
UCEC	TFRC →	+0.457	+1.906	.004	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 30 associations by consensus.

p62 Lck ligand by ZNF606 expression — UCEC

Explore this box plot interactively →