ZNF606

Across TCGA cell cohorts, ZNF606 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,666 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF606-associated GO terms across cancer lineages are Regulation of syncytium formation by plasma membrane fusion, Regulation of myoblast fusion, and Negative regulation of myoblast fusion. Each is linked with ZNF606 in more than 17 cancer types. Because this analysis shows association rather than direction, both ZNF606-to-partner and partner-to-ZNF606 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of syncytium formation by plasma membrane fusion grouped by ZNF606-low versus ZNF606-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF606→partner) and Y-score (partner→ZNF606) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Regulation of syncytium formation by plasma membrane fusion →	+0.076	+0.815	.002	.006	3	18
STOMACH	Regulation of myoblast fusion →	+0.093	+1.486	.003	.005	3	17
BREAST	Negative regulation of myoblast fusion →	+0.147	+1.780	<.001	<.001	3	17
BREAST	Negative regulation of syncytium formation by plasma membrane fusion →	+0.145	+1.771	<.001	<.001	3	17
BREAST	Regulation of mRNA processing →	+0.098	+1.464	<.001	<.001	3	16
SKIN	mRNA export from nucleus →	+0.082	+0.928	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,666 associations by consensus.

Regulation of syncytium formation by plasma membrane fusion by ZNF606 expression — LUNG_SCLC

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