Across TCGA patient cohorts, ZNF605 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF605-associated genes across cancer lineages are C-Raf, eIF4E, and JNK_pT183_Y185. Each is linked with ZNF605 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF605-to-partner and partner-to-ZNF605 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF605→partner) and Y-score (partner→ZNF605) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.106	+2.000	.023	.009	3	3
UCEC	eIF4E →	+0.176	+2.321	.010	<.001	3	2
UCEC	JNK_pT183_Y185 →	-0.117	-2.000	.032	.029	3	2
UCEC	MEK1 →	+0.356	+2.736	.002	<.001	3	2
UCEC	Akt_pS473 →	+0.593	+2.502	.010	.001	3	2
UCEC	Akt_pT308 →	+0.554	+1.716	.006	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

Exploration

ZNF605 survival (RNA) · tumor vs normal (RNA) · all ZNF605 data types