Across TCGA patient cohorts, ZNF600 mutation is significantly associated with the total protein of many other genes, with 32 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF600-associated genes across cancer lineages are 14-3-3_beta, A-Raf_pS299, and MEK1. Each is linked with ZNF600 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF600-to-partner and partner-to-ZNF600 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF600→partner) and Y-score (partner→ZNF600) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.073	-2.088	.031	.016	3	2
UCEC	A-Raf_pS299 →	-0.120	-1.906	.002	.015	3	2
UCEC	MEK1 →	+0.501	+3.058	<.001	<.001	3	2
UCEC	Notch1 →	+0.187	+1.874	<.001	.002	3	2
UCEC	p21 →	+0.134	+2.807	.037	.003	3	2
UCEC	PCNA →	+0.186	+1.584	.010	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 32 associations by consensus.

Exploration

ZNF600 survival (RNA) · tumor vs normal (RNA) · all ZNF600 data types