ZNF598

Across TCGA pan-cancer cohorts, ZNF598 mass-spec protein differs between tumor and matched normal tissue in 6 of 18 cancer types tested, making tumor–normal expression one of ZNF598’s most consistent transcriptional readouts.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where ZNF598 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF598 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

CCRCC, LUAD, and LSCC are the cancer types where ZNF598 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF598 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
CCRCC	All	IV	+0.249	<.001	11	view →
LUAD	Female	II,III,IV	+0.398	<.001	9	view →
LSCC	Female	All	+0.375	<.001	8	view →
HNSC	Male	III,IV	+0.339	<.001	8	view →
COAD	Female	All	+0.331	<.001	8	view →
PDAC	Male	All	−0.527	<.001	7	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 6 strongest of 6 lineages.

ZNF598–CCRCC

Open the CCRCC breakdown →