ZNF597

Across TCGA patient cohorts, ZNF597 RNA expression is significantly associated with the mutation status of many other genes, with 8,799 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF597-associated genes across cancer lineages are PIK3CA, TP53, and RP1. Each is linked with ZNF597 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF597-to-partner and partner-to-ZNF597 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PIK3CA grouped by ZNF597-low versus ZNF597-high in STAD.

RNA expression associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF597→partner) and Y-score (partner→ZNF597) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	PIK3CA →	+2.750	+0.341	.002	.004	3	4
BRCA	TP53 →	-0.892	-0.371	<.001	<.001	3	4
UCEC	RP1 →	+1.426	+0.371	<.001	<.001	3	3
UCEC	HIVEP2 →	+2.180	+0.349	<.001	<.001	3	3
UCEC	FN1 →	+1.137	+0.369	<.001	<.001	3	3
UCEC	SYNE1 →	+1.328	+0.272	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 8,799 associations by consensus.

PIK3CA by ZNF597 expression — STAD

Explore this box plot interactively →