ZNF597

Across TCGA patient cohorts, ZNF597 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF597-associated genes across cancer lineages are MSH2, 14-3-3_epsilon, and TFRC. Each is linked with ZNF597 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF597-to-partner and partner-to-ZNF597 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH2 grouped by ZNF597-low versus ZNF597-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF597→partner) and Y-score (partner→ZNF597) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MSH2 →	+0.258	+3.186	.032	.010	3	1
SKCM	14-3-3_epsilon →	+0.173	+3.186	.008	.010	3	1
SKCM	TFRC →	+0.658	+3.169	.030	.019	3	1
UCEC	eIF4E →	+0.188	+2.700	.047	.006	3	1
UCEC	JNK_pT183_Y185 →	-0.219	-3.169	.003	.019	3	1
UCEC	JNK2 →	+0.206	+2.000	.021	.032	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

MSH2 by ZNF597 expression — SKCM

Explore this box plot interactively →