ZNF596

Across TCGA patient cohorts, ZNF596 mutation is significantly associated with the RNA expression of many other genes, with 3,612 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF596-associated genes across cancer lineages are MBD3L3, TTTY12, and RNA5SP411. Each is linked with ZNF596 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF596-to-partner and partner-to-ZNF596 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MBD3L3 grouped by ZNF596-low versus ZNF596-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF596→partner) and Y-score (partner→ZNF596) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	MBD3L3 →	+0.466	+5.144	<.001	.003	3	2
CESC	TTTY12 →	+0.044	+4.812	<.001	.006	3	2
UCEC	RNA5SP411 →	+1.094	+1.978	<.001	<.001	3	2
UCEC	RNA5SP412 →	+0.616	+1.889	<.001	.002	3	2
UCEC	HMX3 →	+0.409	+1.839	.005	<.001	3	2
UCEC	TRAJ57 →	+0.426	+2.240	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,612 associations by consensus.

MBD3L3 by ZNF596 expression — CESC

Explore this box plot interactively →