ZNF596

Across TCGA patient cohorts, ZNF596 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF596-associated genes across cancer lineages are EGFR_pY1068, PDCD4, and STAT3_pY705. Each is linked with ZNF596 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF596-to-partner and partner-to-ZNF596 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZNF596-low versus ZNF596-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF596→partner) and Y-score (partner→ZNF596) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.250	-2.736	.006	<.001	3	2
UCEC	PDCD4 →	-0.620	-1.896	<.001	.015	3	2
UCEC	STAT3_pY705 →	-0.413	-1.668	<.001	.021	3	2
UCEC	INPP4B →	-0.264	-1.874	.026	.049	3	1
UCEC	JNK_pT183_Y185 →	-0.193	-2.723	.001	<.001	3	1
UCEC	MEK1 →	+0.357	+2.247	.007	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

EGFR_pY1068 by ZNF596 expression — UCEC

Explore this box plot interactively →