ZNF594

Across TCGA patient cohorts, ZNF594 mutation is significantly associated with the RNA expression of many other genes, with 3,564 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF594-associated genes across cancer lineages are TRIM16L, CEP89, and AUNIP. Each is linked with ZNF594 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF594-to-partner and partner-to-ZNF594 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TRIM16L grouped by ZNF594-low versus ZNF594-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF594→partner) and Y-score (partner→ZNF594) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TRIM16L →	+0.597	+1.513	<.001	<.001	3	3
UCEC	CEP89 →	+0.264	+1.847	.007	<.001	3	3
UCEC	AUNIP →	+0.481	+2.032	.001	.004	3	3
UCEC	UBAC1 →	+0.318	+1.599	<.001	<.001	3	3
UCEC	TPGS2 →	+0.316	+2.169	.005	.002	3	3
UCEC	FEM1A →	+0.271	+2.424	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,564 associations by consensus.

TRIM16L by ZNF594 expression — UCEC

Explore this box plot interactively →