ZNF594

Across TCGA patient cohorts, ZNF594 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF594-associated genes across cancer lineages are Acetyl-a-Tubulin-Lys40, JNK_pT183_Y185, and Ku80. Each is linked with ZNF594 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF594-to-partner and partner-to-ZNF594 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Acetyl-a-Tubulin-Lys40 grouped by ZNF594-low versus ZNF594-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF594→partner) and Y-score (partner→ZNF594) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.314	+1.058	.036	.037	3	3
UCEC	JNK_pT183_Y185 →	-0.171	-1.938	<.001	.001	3	2
UCEC	Ku80 →	+0.173	+1.254	.012	.009	3	2
UCEC	MEK1 →	+0.407	+1.857	<.001	<.001	3	2
UCEC	Notch1 →	+0.159	+1.817	<.001	.002	3	2
UCEC	PDCD4 →	-0.431	-1.807	.001	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

Acetyl-a-Tubulin-Lys40 by ZNF594 expression — UCEC

Explore this box plot interactively →