ZNF594

Across TCGA cell cohorts, ZNF594 mutation is significantly associated with the RNA expression of many other genes, with 142 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF594-associated genes across cancer lineages are OR13C8, DPPA5, and MYH2. Each is linked with ZNF594 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF594-to-partner and partner-to-ZNF594 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR13C8 grouped by ZNF594-low versus ZNF594-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF594→partner) and Y-score (partner→ZNF594) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	OR13C8 →	+0.027	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	DPPA5 →	+0.047	+4.544	.002	.003	3	1
BLOOD_Leukemia	MYH2 →	+0.019	+4.786	<.001	<.001	3	1
BLOOD_Leukemia	GOLGA6L2 →	+0.019	+3.705	<.001	.007	3	1
BLOOD_Leukemia	SLITRK1 →	+0.958	+3.855	<.001	.007	3	1
BLOOD_Leukemia	SLC36A2 →	+0.018	+3.551	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 142 associations by consensus.

OR13C8 by ZNF594 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →