ZNF592

Across TCGA pan-cancer cohorts, ZNF592 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF592 data layer compared with 24 for mass-spec protein and 7 for mutation status.

The strongest signal is observed in lung squamous cell carcinoma (LSCC), where higher ZNF592 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF592 expression acts as an unfavorable survival marker, although some lineages such as GBM show a favorable association.

LSCC, CCRCC, and PDAC are the cancer types where ZNF592 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LSCC	DFS	Tertile	II,III,IV	0.790	1.000	.013	16	view →
CCRCC	DFS	Tertile	All	0.545	1.000	.020	3	view →
PDAC	OS	Tertile	All	0.395	0.578	.032	2	view →
GBM	OS	Quartile	All	0.515	0.304	.046	2	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZNF592–LSCC (DFS)

Open the LSCC breakdown →