ZNF592

Across TCGA patient cohorts, ZNF592 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF592-associated genes across cancer lineages are STAT3_pY705, Cyclin-B1, and Ku80. Each is linked with ZNF592 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF592-to-partner and partner-to-ZNF592 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by ZNF592-low versus ZNF592-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF592→partner) and Y-score (partner→ZNF592) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.360	-2.070	<.001	.001	3	3
UCEC	Cyclin-B1 →	+0.539	+2.321	.005	.005	3	3
UCEC	Ku80 →	+0.267	+1.750	.001	.004	3	2
LUSC	GAPDH →	+0.809	+3.009	.020	.019	2	3
COAD	CD49b →	+0.466	+3.008	.002	.019	3	2
COAD	4E-BP1 →	+0.321	+3.008	.004	.019	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

STAT3_pY705 by ZNF592 expression — UCEC

Explore this box plot interactively →