ZNF589

Across TCGA pan-cancer cohorts, ZNF589 Mutation is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF589 data layer compared with 20 for mass-spec protein and 1 for mass-spec protein.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher ZNF589 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated ZNF589 expression acts as an unfavorable survival marker, although some lineages such as BLCA and UCEC show a favorable association.

COAD, BLCA, and SARC are the cancer types where ZNF589 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	OS	Median	All	0.292	0.807	<.001	39	view →
BLCA	DFS	Median	III,IV	1.000	0.267	.017	14	view →
SARC	OS	Median	All	0.133	0.860	<.001	12	view →
UCEC	DFS	Median	All	1.000	0.620	.010	10	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZNF589–COAD (OS)

Open the COAD breakdown →