ZNF589

Across TCGA patient cohorts, ZNF589 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF589-associated genes across cancer lineages are STAT3_pY705, ATM, and ER-alpha_pS118. Each is linked with ZNF589 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF589-to-partner and partner-to-ZNF589 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by ZNF589-low versus ZNF589-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF589→partner) and Y-score (partner→ZNF589) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.345	-1.797	<.001	.025	3	2
UCEC	ATM →	-0.562	-2.000	.001	.010	3	2
BLCA	ER-alpha_pS118 →	+0.134	+3.012	.034	.018	3	1
BLCA	p38-MAPK_pT180_Y182 →	-0.773	-3.000	<.001	.036	3	1
BLCA	Rictor →	-1.029	-3.000	.024	.036	2	2
BLCA	CD20 →	+0.123	+3.025	.015	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

STAT3_pY705 by ZNF589 expression — UCEC

Explore this box plot interactively →