Across TCGA pan-cancer cohorts, ZNF583 Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNF583 data layer compared with 27 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZNF583 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF583 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

UCEC, PRAD, and LUSC are the cancer types where ZNF583 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	0.959	0.619	.017	10	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LUSC	DFS	Median	All	1.000	0.371	.042	4	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →
BLCA	DFS	Median	II,III,IV	0.796	0.331	.048	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: ZNF583 tumor-vs-normal RNA expression · all ZNF583 data types