Across TCGA patient cohorts, ZNF583 mutation is significantly associated with the RNA expression of many other genes, with 2,513 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF583-associated genes across cancer lineages are EME1, MED27, and ZMYND19. Each is linked with ZNF583 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF583-to-partner and partner-to-ZNF583 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF583→partner) and Y-score (partner→ZNF583) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EME1 →	+0.553	+2.265	<.001	.005	3	3
UCEC	MED27 →	+0.470	+3.172	<.001	<.001	3	3
UCEC	ZMYND19 →	+0.485	+2.233	<.001	<.001	3	3
UCEC	CHAF1A →	+0.801	+3.080	<.001	<.001	3	3
UCEC	SF3B2 →	+0.423	+2.524	<.001	<.001	3	3
READ	DEFB117 →	+0.361	+4.421	<.001	.009	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,513 associations by consensus.

Exploration

ZNF583 survival (RNA) · tumor vs normal (RNA) · all ZNF583 data types