Across TCGA cell cohorts, ZNF583 mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ZNF583-associated genes across cancer lineages are OR4F21, ASB17, and KRTAP21-1. Each is linked with ZNF583 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF583-to-partner and partner-to-ZNF583 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF583→partner) and Y-score (partner→ZNF583) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR4F21 →	+0.114	+3.878	.003	.003	3	1
LUNG_NSCLC_LUAD	ASB17 →	+0.029	+4.662	<.001	.005	3	1
LUNG_NSCLC_LUAD	KRTAP21-1 →	+0.025	+5.266	<.001	.001	3	1
LUNG_NSCLC_LUAD	SLC22A25 →	+0.153	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	C9orf92 →	+0.199	+4.212	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR5G3 →	+0.147	+4.212	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

Exploration

ZNF583 survival (RNA) · tumor vs normal (RNA) · all ZNF583 data types