Across TCGA pan-cancer cohorts, ZNF580 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF580 data layer compared with 27 for mass-spec protein and 1 for mutation status.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ZNF580 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF580 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

LUAD, CCRCC, and LSCC are the cancer types where ZNF580 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	III,IV	0.509	1.000	.008	10	view →
CCRCC	DFS	Median	IV	0.137	0.709	.047	6	view →
LSCC	DFS	Quartile	II,III,IV	0.414	1.000	.024	2	view →
PDAC	OS	Median	II,III,IV	1.000	0.690	.040	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: ZNF580 tumor-vs-normal RNA expression · all ZNF580 data types