Across TCGA cell cohorts, ZNF580 mutation is significantly associated with the RNA expression of many other genes, with 9 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF580-associated genes across cancer lineages are ENPP6, SSMEM1, and OR1K1. Each is linked with ZNF580 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF580-to-partner and partner-to-ZNF580 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF580→partner) and Y-score (partner→ZNF580) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	ENPP6 →	+0.046	+3.793	<.001	.007	3	1
LARGE_INTESTINE	SSMEM1 →	+0.036	+3.707	<.001	.009	3	1
LARGE_INTESTINE	OR1K1 →	+0.047	+3.747	.002	.008	3	1
LARGE_INTESTINE	OR1L6 →	+0.022	+4.437	<.001	.004	3	1
LARGE_INTESTINE	KRTAP5-3 →	+0.037	+4.217	<.001	.001	3	1
LARGE_INTESTINE	OOSP4A →	+0.081	+3.793	.003	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 9 associations by consensus.

Exploration

ZNF580 survival (RNA) · tumor vs normal (RNA) · all ZNF580 data types