Across TCGA pan-cancer cohorts, ZNF579 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF579 data layer compared with 27 for mass-spec protein and 2 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher ZNF579 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF579 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

PDAC, HNSC, and LSCC are the cancer types where ZNF579 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.210	0.407	.003	82	view →
HNSC	OS	Median	IV	0.589	0.878	.002	51	view →
LSCC	OS	Median	All	0.721	0.906	.008	11	view →
CCRCC	OS	Median	III,IV	1.000	0.353	.022	3	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: ZNF579 tumor-vs-normal RNA expression · all ZNF579 data types