ZNF578

Across TCGA patient cohorts, ZNF578 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF578-associated genes across cancer lineages are DJ-1, eEF2, and EGFR_pY1068. Each is linked with ZNF578 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF578-to-partner and partner-to-ZNF578 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DJ-1 grouped by ZNF578-low versus ZNF578-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF578→partner) and Y-score (partner→ZNF578) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DJ-1 →	+0.276	+2.824	.002	.034	3	2
UCEC	eEF2 →	+0.296	+1.440	.017	.024	3	2
UCEC	EGFR_pY1068 →	-0.289	-2.999	<.001	<.001	3	2
UCEC	INPP4B →	-0.314	-2.807	.005	.002	3	2
UCEC	MSH2 →	-0.176	-1.973	.028	.029	3	2
UCEC	p27_pT198 →	+0.108	+3.807	.003	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

DJ-1 by ZNF578 expression — LUAD

Explore this box plot interactively →