ZNF578

Across TCGA cell cohorts, ZNF578 RNA expression is significantly associated with the go_rna of many other GO terms, with 1,828 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible ZNF578-associated GO terms across cancer lineages are Regulation of myoblast fusion, Negative regulation of syncytium formation by plasma membrane fusion, and Phospholipase C-activating G protein-coupled receptor signaling pathway. Each is linked with ZNF578 in more than 8 cancer types. Because this analysis shows association rather than direction, both ZNF578-to-partner and partner-to-ZNF578 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of myoblast fusion grouped by ZNF578-low versus ZNF578-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF578→partner) and Y-score (partner→ZNF578) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Regulation of myoblast fusion →	+0.057	+0.641	.002	.002	3	9
BREAST	Negative regulation of syncytium formation by plasma membrane fusion →	+0.089	+0.611	.002	.009	3	8
SKIN	Phospholipase C-activating G protein-coupled receptor signaling pathway →	-0.054	-0.847	<.001	.001	3	7
BREAST	Regulation of syncytium formation by plasma membrane fusion →	+0.063	+0.575	<.001	.003	2	8
LUNG_NSCLC_LUAD	Striated muscle contraction →	+0.026	+0.636	.001	.004	3	7
SOFT_TISSUE	Negative regulation of myoblast fusion →	+0.081	+1.144	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,828 associations by consensus.

Regulation of myoblast fusion by ZNF578 expression — SKIN

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