ZNF578

Across TCGA cell cohorts, ZNF578 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ZNF578-associated genes across cancer lineages are BMP15, NLRP8, and KRTAP3-3. Each is linked with ZNF578 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF578-to-partner and partner-to-ZNF578 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BMP15 grouped by ZNF578-low versus ZNF578-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF578→partner) and Y-score (partner→ZNF578) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	BMP15 →	+0.029	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	NLRP8 →	+0.041	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	KRTAP3-3 →	+0.060	+6.247	<.001	<.001	3	1
SKIN	OR2B2 →	+0.027	+4.684	<.001	.002	3	1
SKIN	KRTAP16-1 →	+0.025	+4.467	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

BMP15 by ZNF578 expression — BLOOD_Lymphoma

Explore this box plot interactively →