ZNF575

Across TCGA patient cohorts, ZNF575 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF575-associated genes across cancer lineages are HNRNPCL3, SNORD116-10, and RNU6-990P. Each is linked with ZNF575 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF575-to-partner and partner-to-ZNF575 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HNRNPCL3 grouped by ZNF575-low versus ZNF575-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF575→partner) and Y-score (partner→ZNF575) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HNRNPCL3 →	+0.093	+3.778	<.001	.007	3	1
UCEC	SNORD116-10 →	+0.455	+4.750	<.001	.005	3	1
UCEC	RNU6-990P →	+0.572	+4.750	<.001	.005	3	1
UCEC	PRAMEF7 →	+0.359	+3.903	<.001	.006	3	1
UCEC	RNU6-32P →	+0.855	+3.911	<.001	.007	3	1
UCEC	RNU6-444P →	+0.764	+4.148	.002	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

HNRNPCL3 by ZNF575 expression — UCEC

Explore this box plot interactively →