ZNF574

Across TCGA pan-cancer cohorts, ZNF574 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNF574 data layer compared with 22 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF574 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF574 expression acts as an unfavorable survival marker, although some lineages such as LSCC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where ZNF574 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.483	0.823	.002	31	view →
LSCC	DFS	Median	All	0.857	0.597	.003	10	view →
PDAC	DFS	Median	II,III,IV	0.677	0.810	.018	9	view →
UCEC	DFS	Median	II,III,IV	0.550	0.857	.033	4	view →
CCRCC	DFS	Median	II,III,IV	0.839	0.964	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZNF574–HNSC (DFS)

Open the HNSC breakdown →