ZNF574

Across TCGA patient cohorts, ZNF574 mutation is significantly associated with the RNA expression of many other genes, with 2,040 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF574-associated genes across cancer lineages are ABHD3, ZNF761, and SAP30. Each is linked with ZNF574 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF574-to-partner and partner-to-ZNF574 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ABHD3 grouped by ZNF574-low versus ZNF574-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF574→partner) and Y-score (partner→ZNF574) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ABHD3 →	+0.589	+1.847	<.001	<.001	3	3
UCEC	ZNF761 →	+0.362	+1.606	.005	.003	3	3
UCEC	SAP30 →	+0.463	+1.606	.003	.003	3	3
UCEC	PBK →	+0.837	+1.847	<.001	<.001	3	3
UCEC	HASPIN →	+0.589	+1.856	<.001	.004	3	3
UCEC	TCF19 →	+0.670	+3.010	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,040 associations by consensus.

ABHD3 by ZNF574 expression — UCEC

Explore this box plot interactively →