ZNF574

Across TCGA patient cohorts, ZNF574 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF574-associated genes across cancer lineages are p62 Lck ligand, PDCD4, and LKB1. Each is linked with ZNF574 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF574-to-partner and partner-to-ZNF574 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ZNF574-low versus ZNF574-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF574→partner) and Y-score (partner→ZNF574) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.398	+2.424	<.001	.001	3	3
UCEC	PDCD4 →	-0.496	-2.584	.002	.010	3	3
COAD	LKB1 →	+0.116	+2.815	.032	.036	3	2
COAD	TIGAR →	+0.719	+2.815	<.001	.036	3	2
COAD	Cyclin-E2 →	+0.381	+2.815	.002	.036	3	2
UCEC	mTOR_pS2448 →	-0.129	-1.440	.012	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

p62 Lck ligand by ZNF574 expression — UCEC

Explore this box plot interactively →