ZNF574

Across TCGA cell cohorts, ZNF574 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,387 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ZNF574-associated GO terms across cancer lineages are Regulation of chromatin organization, Negative regulation of calcium ion export across plasma membrane, and Regulation of protein localization to centrosome. Each is linked with ZNF574 in more than 14 cancer types. Because this analysis shows association rather than direction, both ZNF574-to-partner and partner-to-ZNF574 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of chromatin organization grouped by ZNF574-low versus ZNF574-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF574→partner) and Y-score (partner→ZNF574) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Regulation of chromatin organization →	+0.072	+0.533	<.001	<.001	3	15
STOMACH	Negative regulation of calcium ion export across plasma membrane →	+0.094	+1.119	<.001	<.001	3	15
BONE	Regulation of protein localization to centrosome →	+0.150	+0.810	<.001	<.001	3	14
BONE	Epigenetic regulation of gene expression →	+0.105	+1.046	<.001	<.001	3	14
BONE	Regulation of DNA repair →	+0.090	+0.620	.001	.008	3	13
BONE	Nucleosome disassembly →	+0.182	+0.818	.003	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,387 associations by consensus.

Regulation of chromatin organization by ZNF574 expression — UPPER_AERODIGESTIVE_TRACT

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