Across TCGA patient cohorts, ZNF573 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF573-associated genes across cancer lineages are p38-MAPK_pT180_Y182, Caspase-7-cleavedD198, and GSK-3_pS9. Each is linked with ZNF573 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF573-to-partner and partner-to-ZNF573 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF573→partner) and Y-score (partner→ZNF573) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.594	-2.649	<.001	<.001	3	3
UCEC	Caspase-7-cleavedD198 →	+0.534	+1.604	.016	.041	3	3
UCEC	GSK-3_pS9 →	-0.419	-2.115	.005	.017	3	2
SKCM	Ku80 →	+0.357	+3.321	.012	.010	3	2
UCEC	PCNA →	+0.217	+2.222	.007	.010	3	2
UCEC	S6_pS235_S236 →	-0.324	-1.415	.046	.046	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Exploration

ZNF573 survival (RNA) · tumor vs normal (RNA) · all ZNF573 data types