ZNF572

Across TCGA patient cohorts, ZNF572 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF572-associated genes across cancer lineages are MEK1, ATM, and CDK1. Each is linked with ZNF572 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF572-to-partner and partner-to-ZNF572 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ZNF572-low versus ZNF572-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF572→partner) and Y-score (partner→ZNF572) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.341	+1.514	.006	.015	3	2
COAD	ATM →	-0.674	-3.000	<.001	.034	3	2
COAD	CDK1 →	+0.266	+2.178	.001	.035	3	2
COAD	4E-BP1 →	+0.310	+2.178	.002	.035	3	2
UCEC	Cyclin-B1 →	+0.622	+3.584	.001	.002	3	2
UCEC	EGFR_pY1068 →	-0.225	-2.321	.008	.033	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

MEK1 by ZNF572 expression — UCEC

Explore this box plot interactively →