ZNF571

Across TCGA patient cohorts, ZNF571 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF571-associated genes across cancer lineages are C-Raf, Notch1, and P-Cadherin. Each is linked with ZNF571 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF571-to-partner and partner-to-ZNF571 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by ZNF571-low versus ZNF571-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF571→partner) and Y-score (partner→ZNF571) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.114	+1.440	.021	.024	3	3
UCEC	Notch1 →	+0.123	+1.598	.011	.040	3	2
UCEC	P-Cadherin →	-0.099	-2.321	.048	.033	3	2
UCEC	Cyclin-B1 →	+0.459	+2.321	.018	.033	3	2
UCEC	Di-Ras3 →	-0.120	-2.687	.020	.005	3	2
UCEC	14-3-3_beta →	-0.071	-1.973	.040	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

C-Raf by ZNF571 expression — UCEC

Explore this box plot interactively →