ZNF570

Across TCGA patient cohorts, ZNF570 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF570-associated genes across cancer lineages are Ku80, p62 Lck ligand, and Caspase-7-cleavedD198. Each is linked with ZNF570 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF570-to-partner and partner-to-ZNF570 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by ZNF570-low versus ZNF570-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF570→partner) and Y-score (partner→ZNF570) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.237	+1.498	.012	.036	3	2
UCEC	p62 Lck ligand →	+0.320	+3.321	.014	.009	3	2
UCEC	Caspase-7-cleavedD198 →	+0.592	+2.479	.013	.010	3	2
UCEC	ACC1 →	+0.440	+1.906	.002	.016	3	1
UCEC	MEK1 →	+0.360	+3.321	.014	.010	3	1
UCEC	Notch1 →	+0.214	+2.335	<.001	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

Ku80 by ZNF570 expression — UCEC

Explore this box plot interactively →