ZNF570

Across TCGA cell cohorts, ZNF570 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ZNF570-associated genes across cancer lineages are C1orf189, REG1B, and DEFB125. Each is linked with ZNF570 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF570-to-partner and partner-to-ZNF570 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C1orf189 grouped by ZNF570-low versus ZNF570-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF570→partner) and Y-score (partner→ZNF570) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	C1orf189 →	+0.179	+3.632	<.001	.009	3	2
LARGE_INTESTINE	REG1B →	+3.867	+3.196	<.001	.007	3	2
BLOOD_Leukemia	DEFB125 →	+0.035	+4.060	<.001	.003	3	1
BLOOD_Lymphoma	CCL11 →	+0.018	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	HSFY1 →	+0.026	+5.209	<.001	.005	3	1
LUNG_NSCLC_LUAD	IFNK →	+0.031	+4.371	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

C1orf189 by ZNF570 expression — STOMACH

Explore this box plot interactively →