ZNF57

Across TCGA patient cohorts, ZNF57 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF57-associated genes across cancer lineages are MSH6, PDCD4, and ATM. Each is linked with ZNF57 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF57-to-partner and partner-to-ZNF57 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MSH6 grouped by ZNF57-low versus ZNF57-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF57→partner) and Y-score (partner→ZNF57) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MSH6 →	-0.409	-2.321	.002	.033	3	2
UCEC	PDCD4 →	-0.503	-2.321	.009	.006	3	2
UCEC	ATM →	-0.443	-1.807	.018	.027	3	2
UCEC	Caspase-7-cleavedD198 →	+0.723	+3.604	.003	.001	3	2
UCEC	Cyclin-B1 →	+0.515	+2.321	.026	.006	3	2
UCEC	EGFR_pY1068 →	-0.275	-3.584	.008	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

MSH6 by ZNF57 expression — UCEC

Explore this box plot interactively →