Across TCGA patient cohorts, ZNF566 mutation is significantly associated with the total protein of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF566-associated genes across cancer lineages are A-Raf_pS299, HER2_pY1248, and 14-3-3_beta. Each is linked with ZNF566 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF566-to-partner and partner-to-ZNF566 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF566→partner) and Y-score (partner→ZNF566) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	A-Raf_pS299 →	-0.136	-3.459	.005	.005	3	2
SKCM	HER2_pY1248 →	+0.255	+2.321	<.001	.035	3	2
UCEC	14-3-3_beta →	-0.107	-3.432	.010	.005	3	1
UCEC	ERK2 →	+0.285	+2.584	<.001	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.201	-2.584	.003	.010	3	1
UCEC	Ku80 →	+0.227	+1.820	.020	.016	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

Exploration

ZNF566 survival (RNA) · tumor vs normal (RNA) · all ZNF566 data types