ZNF564

Across TCGA patient cohorts, ZNF564 mutation is significantly associated with the RNA expression of many other genes, with 3,718 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF564-associated genes across cancer lineages are MELK, SPATA5L1, and DEPDC1. Each is linked with ZNF564 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF564-to-partner and partner-to-ZNF564 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MELK grouped by ZNF564-low versus ZNF564-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF564→partner) and Y-score (partner→ZNF564) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MELK →	+0.849	+3.917	<.001	<.001	3	3
UCEC	SPATA5L1 →	+0.546	+2.885	<.001	<.001	3	3
SKCM	DEPDC1 →	+0.836	+3.207	.007	.009	3	3
UCEC	MCM6 →	+0.616	+3.584	.001	.002	3	3
COAD	RNU1-35P →	+0.260	+3.476	.005	.005	3	3
UCEC	MRPL18 →	+0.432	+2.917	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,718 associations by consensus.

MELK by ZNF564 expression — UCEC

Explore this box plot interactively →