Across TCGA patient cohorts, ZNF563 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF563-associated genes across cancer lineages are c-Met_pY1235, EGFR_pY1068, and EGFR. Each is linked with ZNF563 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF563-to-partner and partner-to-ZNF563 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF563→partner) and Y-score (partner→ZNF563) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Met_pY1235 →	+0.052	+1.594	.033	.010	3	2
UCEC	EGFR_pY1068 →	-0.272	-2.999	<.001	<.001	3	1
UCEC	EGFR →	-0.174	-2.089	<.001	.016	3	1
UCEC	FASN →	+0.309	+1.938	.017	.001	3	1
UCEC	FoxM1 →	+0.279	+1.938	.001	.001	3	1
UCEC	INPP4B →	-0.287	-2.807	.007	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

Exploration

ZNF563 survival (RNA) · tumor vs normal (RNA) · all ZNF563 data types