ZNF562

Across TCGA patient cohorts, ZNF562 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF562-associated genes across cancer lineages are EGFR_pY1068, p21, and Bax. Each is linked with ZNF562 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF562-to-partner and partner-to-ZNF562 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EGFR_pY1068 grouped by ZNF562-low versus ZNF562-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF562→partner) and Y-score (partner→ZNF562) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	EGFR_pY1068 →	-0.318	-2.584	.003	.010	3	2
UCEC	p21 →	+0.175	+3.169	.037	.019	3	2
UCEC	Bax →	+0.349	+2.009	<.001	.017	3	2
UCEC	Caspase-7-cleavedD198 →	+0.604	+3.189	.019	.010	3	2
UCEC	eEF2 →	+0.445	+3.321	.004	.010	3	1
UCEC	ERK2 →	+0.183	+2.115	.029	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

EGFR_pY1068 by ZNF562 expression — UCEC

Explore this box plot interactively →