ZNF561-AS1

Across TCGA pan-cancer cohorts, ZNF561-AS1 RNA is linked to patient survival in 22 of 34 cancer types, making it the most broadly survival-associated ZNF561-AS1 data layer.

The strongest signal is observed in uveal melanoma (UVM), where higher ZNF561-AS1 RNA is associated with better overall survival. In most high-consensus cancer types, elevated ZNF561-AS1 expression acts as an unfavorable survival marker, although some lineages such as UVM and KIRP show a favorable association.

UVM, KICH, and KIRP are the cancer types where ZNF561-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UVM	OS	Median	All	0.845	0.413	<.001	106	view →
KICH	DFS	Median	All	0.678	0.976	<.001	80	view →
KIRP	OS	Quartile	All	0.965	0.846	.002	51	view →
SKCM	OS	Tertile	All	0.767	0.915	.001	46	view →
LIHC	OS	Tertile	All	0.661	0.844	.002	35	view →
THYM	DFS	Tertile	All	0.964	0.724	.002	26	view →
KIRC	OS	Median	All	0.704	0.571	.006	22	view →
OV	OS	Median	IV	0.492	0.268	.006	22	view →
STAD	OS	Median	All	0.422	0.626	.005	21	view →
BRCA	DFS	Median	All	0.962	0.935	.011	18	view →
UCS	OS	Median	II,III,IV	0.774	0.451	.009	18	view →
HNSC	OS	Median	III,IV	0.591	0.756	.019	11	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 22 lineages.

ZNF561-AS1–UVM (OS)

Open the UVM breakdown →