ZNF557

Across TCGA patient cohorts, ZNF557 mutation is significantly associated with the RNA expression of many other genes, with 3,048 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF557-associated genes across cancer lineages are CINP, RN7SKP291, and RNVU1-18. Each is linked with ZNF557 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF557-to-partner and partner-to-ZNF557 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CINP grouped by ZNF557-low versus ZNF557-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF557→partner) and Y-score (partner→ZNF557) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	CINP →	+0.321	+2.112	<.001	<.001	3	3
SKCM	RN7SKP291 →	+0.071	+4.624	<.001	<.001	3	2
SKCM	RNVU1-18 →	+0.118	+3.159	.001	.008	3	2
UCEC	ANKRD54 →	+0.336	+2.058	.004	<.001	3	2
UCEC	RTCB →	+0.371	+2.276	.007	.005	3	2
UCEC	SAMM50 →	+0.364	+3.480	.006	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,048 associations by consensus.

CINP by ZNF557 expression — UCEC

Explore this box plot interactively →