ZNF557

Across TCGA cell cohorts, ZNF557 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,786 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ZNF557-associated GO terms across cancer lineages are Subtelomeric heterochromatin formation, Heterochromatin formation, and Epigenetic regulation of gene expression. Each is linked with ZNF557 in more than 14 cancer types. Because this analysis shows association rather than direction, both ZNF557-to-partner and partner-to-ZNF557 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Subtelomeric heterochromatin formation grouped by ZNF557-low versus ZNF557-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF557→partner) and Y-score (partner→ZNF557) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Subtelomeric heterochromatin formation →	+0.111	+0.584	<.001	<.001	3	15
STOMACH	Heterochromatin formation →	+0.065	+0.665	.003	<.001	3	14
LUNG_SCLC	Epigenetic regulation of gene expression →	+0.063	+0.641	<.001	.001	3	14
LUNG_SCLC	Negative regulation of gene expression, epigenetic →	+0.059	+0.557	<.001	.005	3	14
STOMACH	Heterochromatin organization →	+0.062	+0.728	.002	<.001	3	14
SKIN	Host-mediated activation of viral process →	+0.066	+0.426	.001	.002	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,786 associations by consensus.

Subtelomeric heterochromatin formation by ZNF557 expression — LUNG_SCLC

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