ZNF554

Across TCGA patient cohorts, ZNF554 mutation is significantly associated with the total protein of many other genes, with 31 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF554-associated genes across cancer lineages are c-Jun_pS73, eEF2, and EGFR_pY1068. Each is linked with ZNF554 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF554-to-partner and partner-to-ZNF554 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Jun_pS73 grouped by ZNF554-low versus ZNF554-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF554→partner) and Y-score (partner→ZNF554) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	c-Jun_pS73 →	-0.125	-3.156	.045	.018	3	2
UCEC	eEF2 →	+0.296	+1.584	.035	.036	3	1
UCEC	EGFR_pY1068 →	-0.254	-2.000	.009	.010	3	1
UCEC	A-Raf_pS299 →	-0.129	-2.459	.005	.019	3	1
UCEC	GATA6 →	-0.145	-1.577	.017	.036	3	1
UCEC	IGFBP2 →	-0.663	-2.999	.009	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 31 associations by consensus.

c-Jun_pS73 by ZNF554 expression — UCEC

Explore this box plot interactively →